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B-cell lymphomas : ウィキペディア英語版
Lymphoma


Lymphoma is any of a group of blood cell tumors that develop from lymphatic cells. The name often refers to just the cancerous ones rather than all such tumors. Signs and symptoms may include enlarged lymph nodes, fever, drenching sweats, unintended weight loss, itching, and feeling tired.〔〔 The enlarged lymph nodes are usually painless.〔 The sweats are most common at night.

There are dozens of subtypes of lymphomas. The two main categories of lymphomas are Hodgkin lymphomas (HL) and the non-Hodgkin lymphomas (NHL). The World Health Organization (WHO) includes two other categories as types of lymphoma: multiple myeloma and immunoproliferative diseases.〔 About 90% of lymphomas are non-Hodgkin lymphomas.〔〔(【引用サイトリンク】url=http://www.cancer.gov/dictionary?cdrid=45368 )〕 Lymphomas and leukemias are a part of the broader group of tumors of the hematopoietic and lymphoid tissues.

Risk factors for Hodgkin lymphoma include infection with Epstein–Barr virus and a history of the disease in the family.〔 Risk factors for common types of non-Hodgkin lymphomas include autoimmune diseases, HIV/AIDS, infection with human T-lymphotropic virus, eating a large amount of meat and fat, immunosuppressant medications, and some pesticides.〔 Diagnosis, if enlarged lymph nodes are present, is usually by lymph node biopsy.〔〔 Blood, urine, and bone marrow testing may also be useful in the diagnosis.〔 Medical imaging may then be done to determine if and where the cancer has spread.〔〔 Lymphoma most often spreads to the lungs, liver, and/or brain.〔〔

Treatment may involve one or more of the following: chemotherapy, radiation therapy, targeted therapy, and surgery.〔〔 In some non-Hodgkin lymphomas, an increased amount of protein produced by the lymphoma cells causes the blood to become so thick that plasmapheresis is performed to remove the protein.〔 Watchful waiting may be appropriate for certain types.〔 The outcome depends on the subtype with some being curable and treatment prolongs survival in most.〔 The five-year survival rate in the United States for all Hodgkin lymphoma subtypes is 85%,〔(【引用サイトリンク】title=Hodgkin Lymphoma—SEER Stat Fact Sheets )〕 while that for non-Hodgkin lymphomas it is 69%.〔(【引用サイトリンク】url=http://seer.cancer.gov/statfacts/html/nhl.html ) Worldwide, lymphomas developed in 566,000 people in 2012 and caused 305,000 deaths. They make up 3–4% of all cancers, making them as a group the seventh-most common form.〔 In children, they are the third-most common cancer. They occur more often in the developed world than the developing world.〔
==Signs and symptoms==

Lymphoma may present with certain nonspecific symptoms; if the symptoms are persistent, an evaluation to determine their cause, including possible lymphoma, should be undertaken.
*Lymphadenopathy〔(【引用サイトリンク】url=http://www.lymphoma.org/site/pp.asp?c=bkLTKaOQLmK8E&b=6299689 )〕〔 or swelling of lymph nodes, is the primary presentation in lymphoma.
*B symptoms (systemic symptoms) – can be associated with both Hodgkin lymphoma and non-Hodgkin lymphoma. They consist of:
*
*Fever〔〔
*
*Night sweats〔〔
*
*Weight loss〔〔
*Other symptoms :
*
*Loss of appetite or anorexia〔(【引用サイトリンク】title=Warning Signs of Lymphoma — First Signs of Lymphoma )
*
*Fatigue〔〔
*
*Respiratory distress or dyspnea
*
*Itching〔〔

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「Lymphoma」の詳細全文を読む



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